{
  "cohorts": [
    {
      "id": "FamF",
      "source": "exp.Analysis FamF(1).txt",
      "rows": 54675,
      "columns": 24,
      "missing": 0,
      "range": [
        2.88128,
        15.39215
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      "samples": [
        {
          "label": "George 10 PCJB",
          "phenotype": "Normal, HU-",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_D_M_J010",
          "classification": "unknown",
          "group": null,
          "file": "George 10 PCJB.CEL",
          "id": "10",
          "treatment": "Untreated",
          "cohort": "FamF"
        },
        {
          "label": "George 10 PHJB",
          "phenotype": "Normal, HU+",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_D_U_J010",
          "classification": "unknown",
          "group": null,
          "file": "George 10 PHJB.CEL",
          "id": "10",
          "treatment": "HU",
          "cohort": "FamF"
        },
        {
          "label": "George 11 PCJB",
          "phenotype": "Normal, HU-",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_D_M_J011",
          "classification": "unknown",
          "group": null,
          "file": "George 11 PCJB.CEL",
          "id": "11",
          "treatment": "Untreated",
          "cohort": "FamF"
        },
        {
          "label": "George 11 PHJB",
          "phenotype": "Normal, HU+",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_D_U_J011",
          "classification": "unknown",
          "group": null,
          "file": "George 11 PHJB.CEL",
          "id": "11",
          "treatment": "HU",
          "cohort": "FamF"
        },
        {
          "label": "George 12 PCJB",
          "phenotype": "Middle HbF, HU-",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_M_J012",
          "classification": "unknown",
          "group": null,
          "file": "George 12 PCJB.CEL",
          "id": "12",
          "treatment": "Untreated",
          "cohort": "FamF"
        },
        {
          "label": "George 12 PHJB",
          "phenotype": "Middle HbF, HU+",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_U_J012",
          "classification": "unknown",
          "group": null,
          "file": "George 12 PHJB.CEL",
          "id": "12",
          "treatment": "HU",
          "cohort": "FamF"
        },
        {
          "label": "George 13 PCJB",
          "phenotype": "High HbF, HU-",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_M_J013",
          "classification": "wt/-",
          "group": "G",
          "file": "George 13 PCJB.CEL",
          "id": "13",
          "treatment": "Untreated",
          "cohort": "FamF"
        },
        {
          "label": "George 13 PHJB",
          "phenotype": "High HbF, HU+",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_U_J013",
          "classification": "wt/-",
          "group": "H",
          "file": "George 13 PHJB.CEL",
          "id": "13",
          "treatment": "HU",
          "cohort": "FamF"
        },
        {
          "label": "George 14 PCJB",
          "phenotype": "Middle HbF, HU-",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_M_J014",
          "classification": "wt/-",
          "group": "G",
          "file": "George 14 PCJB.CEL",
          "id": "14",
          "treatment": "Untreated",
          "cohort": "FamF"
        },
        {
          "label": "George 14 PHJB",
          "phenotype": "Middle HbF, HU+",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_U_J014",
          "classification": "wt/-",
          "group": "H",
          "file": "George 14 PHJB.CEL",
          "id": "14",
          "treatment": "HU",
          "cohort": "FamF"
        },
        {
          "label": "George 15 PCJB",
          "phenotype": "Middle HbF, HU-",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_M_J015",
          "classification": "wt/wt",
          "group": "E",
          "file": "George 15 PCJB.CEL",
          "id": "15",
          "treatment": "Untreated",
          "cohort": "FamF"
        },
        {
          "label": "George 15 PHJB",
          "phenotype": "Middle HbF, HU+",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_U_J015",
          "classification": "wt/wt",
          "group": "F",
          "file": "George 15 PHJB.CEL",
          "id": "15",
          "treatment": "HU",
          "cohort": "FamF"
        },
        {
          "label": "George 2 PCJB",
          "phenotype": "Middle HbF, HU-",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_M_J002",
          "classification": "unknown",
          "group": null,
          "file": "George 2 PCJB.CEL",
          "id": "2",
          "treatment": "Untreated",
          "cohort": "FamF"
        },
        {
          "label": "George 2 PHJB",
          "phenotype": "Middle HbF, HU+",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_U_J002",
          "classification": "unknown",
          "group": null,
          "file": "George 2 PHJB.CEL",
          "id": "2",
          "treatment": "HU",
          "cohort": "FamF"
        },
        {
          "label": "George 3 PCJB",
          "phenotype": "Normal, HU-",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_D_M_J003",
          "classification": "wt/wt",
          "group": "E",
          "file": "George 3 PCJB.CEL",
          "id": "3",
          "treatment": "Untreated",
          "cohort": "FamF"
        },
        {
          "label": "George 3 PHJB",
          "phenotype": "Normal, HU+",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_D_U_J003",
          "classification": "wt/wt",
          "group": "F",
          "file": "George 3 PHJB.CEL",
          "id": "3",
          "treatment": "HU",
          "cohort": "FamF"
        },
        {
          "label": "George 4 PCJB",
          "phenotype": "Normal, HU-",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_D_M_J004",
          "classification": "wt/wt",
          "group": "E",
          "file": "George 4 PCJB.CEL",
          "id": "4",
          "treatment": "Untreated",
          "cohort": "FamF"
        },
        {
          "label": "George 4 PHJB",
          "phenotype": "Normal, HU+",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_D_U_J004",
          "classification": "wt/wt",
          "group": "F",
          "file": "George 4 PHJB.CEL",
          "id": "4",
          "treatment": "HU",
          "cohort": "FamF"
        },
        {
          "label": "George 5 PCJB",
          "phenotype": "Middle HbF, HU-",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_M_J005",
          "classification": "wt/-",
          "group": "G",
          "file": "George 5 PCJB.CEL",
          "id": "5",
          "treatment": "Untreated",
          "cohort": "FamF"
        },
        {
          "label": "George 5 PHJB",
          "phenotype": "Middle HbF, HU+",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_U_J005",
          "classification": "wt/-",
          "group": "H",
          "file": "George 5 PHJB.CEL",
          "id": "5",
          "treatment": "HU",
          "cohort": "FamF"
        },
        {
          "label": "George 6 PCJB",
          "phenotype": "Normal, HU-",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_D_M_J006",
          "classification": "wt/wt",
          "group": "E",
          "file": "George 6 PCJB.CEL",
          "id": "6",
          "treatment": "Untreated",
          "cohort": "FamF"
        },
        {
          "label": "George 6 PHJB",
          "phenotype": "Normal, HU+",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_D_U_J006",
          "classification": "wt/wt",
          "group": "F",
          "file": "George 6 PHJB.CEL",
          "id": "6",
          "treatment": "HU",
          "cohort": "FamF"
        },
        {
          "label": "George 8 PCJB",
          "phenotype": "Middle HbF, HU-",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_M_J008",
          "classification": "wt/-",
          "group": "G",
          "file": "George 8 PCJB.CEL",
          "id": "8",
          "treatment": "Untreated",
          "cohort": "FamF"
        },
        {
          "label": "George 8 PHJB",
          "phenotype": "Middle HbF, HU+",
          "material": "Peripheral Blood",
          "date": "Jan. 2009",
          "array_id": "P_H_U_J008",
          "classification": "wt/-",
          "group": "H",
          "file": "George 8 PHJB.CEL",
          "id": "8",
          "treatment": "HU",
          "cohort": "FamF"
        }
      ],
      "pairs": [
        {
          "id": "10",
          "pc": 0,
          "ph": 1,
          "group": "Uncertain",
          "classification": "unknown",
          "primary": false,
          "phenotype": "Normal, HU-"
        },
        {
          "id": "11",
          "pc": 2,
          "ph": 3,
          "group": "Uncertain",
          "classification": "unknown",
          "primary": false,
          "phenotype": "Normal, HU-"
        },
        {
          "id": "12",
          "pc": 4,
          "ph": 5,
          "group": "Uncertain",
          "classification": "unknown",
          "primary": false,
          "phenotype": "Middle HbF, HU-"
        },
        {
          "id": "13",
          "pc": 6,
          "ph": 7,
          "group": "KLF1",
          "classification": "wt/-",
          "primary": true,
          "phenotype": "High HbF, HU-"
        },
        {
          "id": "14",
          "pc": 8,
          "ph": 9,
          "group": "KLF1",
          "classification": "wt/-",
          "primary": true,
          "phenotype": "Middle HbF, HU-"
        },
        {
          "id": "15",
          "pc": 10,
          "ph": 11,
          "group": "WT",
          "classification": "wt/wt",
          "primary": true,
          "phenotype": "Middle HbF, HU-"
        },
        {
          "id": "2",
          "pc": 12,
          "ph": 13,
          "group": "Uncertain",
          "classification": "unknown",
          "primary": false,
          "phenotype": "Middle HbF, HU-"
        },
        {
          "id": "3",
          "pc": 14,
          "ph": 15,
          "group": "WT",
          "classification": "wt/wt",
          "primary": true,
          "phenotype": "Normal, HU-"
        },
        {
          "id": "4",
          "pc": 16,
          "ph": 17,
          "group": "WT",
          "classification": "wt/wt",
          "primary": true,
          "phenotype": "Normal, HU-"
        },
        {
          "id": "5",
          "pc": 18,
          "ph": 19,
          "group": "KLF1",
          "classification": "wt/-",
          "primary": true,
          "phenotype": "Middle HbF, HU-"
        },
        {
          "id": "6",
          "pc": 20,
          "ph": 21,
          "group": "WT",
          "classification": "wt/wt",
          "primary": true,
          "phenotype": "Normal, HU-"
        },
        {
          "id": "8",
          "pc": 22,
          "ph": 23,
          "group": "KLF1",
          "classification": "wt/-",
          "primary": true,
          "phenotype": "Middle HbF, HU-"
        }
      ]
    },
    {
      "id": "Greek",
      "source": "GREEK_exp.Analysis 1.txt",
      "rows": 54675,
      "columns": 30,
      "missing": 0,
      "range": [
        2.69327,
        15.27143
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      "samples": [
        {
          "label": "George 23PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M023",
          "classification": "R",
          "group": "C",
          "file": "George 23PC.CEL",
          "id": "23",
          "treatment": "Untreated",
          "cohort": "Greek"
        },
        {
          "label": "George 23PH",
          "phenotype": "Sickle Cell Anemia, HU+",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_U_M023",
          "classification": "R",
          "group": "D",
          "file": "George 23PH.CEL",
          "id": "23",
          "treatment": "HU",
          "cohort": "Greek"
        },
        {
          "label": "George 24PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M024",
          "classification": "R",
          "group": "C",
          "file": "George 24PC.CEL",
          "id": "24",
          "treatment": "Untreated",
          "cohort": "Greek"
        },
        {
          "label": "George 24PH",
          "phenotype": "Sickle Cell Anemia, HU+",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_U_M024",
          "classification": "R",
          "group": "D",
          "file": "George 24PH.CEL",
          "id": "24",
          "treatment": "HU",
          "cohort": "Greek"
        },
        {
          "label": "George 25PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M025",
          "classification": "NR",
          "group": "A",
          "file": "George 25PC.CEL",
          "id": "25",
          "treatment": "Untreated",
          "cohort": "Greek"
        },
        {
          "label": "George 25PH",
          "phenotype": "Sickle Cell Anemia, HU+",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_U_M025",
          "classification": "NR",
          "group": "B",
          "file": "George 25PH.CEL",
          "id": "25",
          "treatment": "HU",
          "cohort": "Greek"
        },
        {
          "label": "George_r 18PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M018",
          "classification": "NR",
          "group": "A",
          "file": "George_r 18PC.CEL",
          "id": "18",
          "treatment": "Untreated",
          "cohort": "Greek"
        },
        {
          "label": "George_r 18PH",
          "phenotype": "Sickle Cell Anemia, HU+",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_U_M018",
          "classification": "NR",
          "group": "B",
          "file": "George_r 18PH.CEL",
          "id": "18",
          "treatment": "HU",
          "cohort": "Greek"
        },
        {
          "label": "George_r 19PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M019",
          "classification": "R?",
          "group": null,
          "file": "George_r 19PC.CEL",
          "id": "19",
          "treatment": "Untreated",
          "cohort": "Greek"
        },
        {
          "label": "George_r 19PH",
          "phenotype": "Sickle Cell Anemia, HU+",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_U_M019",
          "classification": "R?",
          "group": null,
          "file": "George_r 19PH.CEL",
          "id": "19",
          "treatment": "HU",
          "cohort": "Greek"
        },
        {
          "label": "George_r 1PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M001",
          "classification": "NR?",
          "group": null,
          "file": "George_r 1PC.CEL",
          "id": "1",
          "treatment": "Untreated",
          "cohort": "Greek"
        },
        {
          "label": "George_r 1PH",
          "phenotype": "Sickle Cell Anemia, HU+",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_U_M001",
          "classification": "NR?",
          "group": null,
          "file": "George_r 1PH.CEL",
          "id": "1",
          "treatment": "HU",
          "cohort": "Greek"
        },
        {
          "label": "George_r 20PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M020",
          "classification": "R?",
          "group": null,
          "file": "George_r 20PC.CEL",
          "id": "20",
          "treatment": "Untreated",
          "cohort": "Greek"
        },
        {
          "label": "George_r 20PH",
          "phenotype": "Sickle Cell Anemia, HU+",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_U_M020",
          "classification": "R?",
          "group": null,
          "file": "George_r 20PH.CEL",
          "id": "20",
          "treatment": "HU",
          "cohort": "Greek"
        },
        {
          "label": "George_r 21PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M021",
          "classification": "NR",
          "group": "A",
          "file": "George_r 21PC.CEL",
          "id": "21",
          "treatment": "Untreated",
          "cohort": "Greek"
        },
        {
          "label": "George_r 21PH",
          "phenotype": "Sickle Cell Anemia, HU+",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_U_M021",
          "classification": "NR",
          "group": "B",
          "file": "George_r 21PH.CEL",
          "id": "21",
          "treatment": "HU",
          "cohort": "Greek"
        },
        {
          "label": "George_r 22PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M022",
          "classification": "NR?",
          "group": null,
          "file": "George_r 22PC.CEL",
          "id": "22",
          "treatment": "Untreated",
          "cohort": "Greek"
        },
        {
          "label": "George_r 22PH",
          "phenotype": "Sickle Cell Anemia, HU+",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_U_M022",
          "classification": "NR?",
          "group": null,
          "file": "George_r 22PH.CEL",
          "id": "22",
          "treatment": "HU",
          "cohort": "Greek"
        },
        {
          "label": "George_r 2PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M002",
          "classification": "NR?",
          "group": null,
          "file": "George_r 2PC.CEL",
          "id": "2",
          "treatment": "Untreated",
          "cohort": "Greek"
        },
        {
          "label": "George_r 2PH",
          "phenotype": "Sickle Cell Anemia, HU+",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_U_M002",
          "classification": "NR?",
          "group": null,
          "file": "George_r 2PH.CEL",
          "id": "2",
          "treatment": "HU",
          "cohort": "Greek"
        },
        {
          "label": "George_r 3PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M003",
          "classification": "R?",
          "group": null,
          "file": "George_r 3PC.CEL",
          "id": "3",
          "treatment": "Untreated",
          "cohort": "Greek"
        },
        {
          "label": "George_r 3PH",
          "phenotype": "Sickle Cell Anemia, HU+",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_U_M003",
          "classification": "R?",
          "group": null,
          "file": "George_r 3PH.CEL",
          "id": "3",
          "treatment": "HU",
          "cohort": "Greek"
        },
        {
          "label": "George_r 4PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M004",
          "classification": "NR",
          "group": "A",
          "file": "George_r 4PC.CEL",
          "id": "4",
          "treatment": "Untreated",
          "cohort": "Greek"
        },
        {
          "label": "George_r 4PH",
          "phenotype": "Sickle Cell Anemia, HU+",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_U_M004",
          "classification": "NR",
          "group": "B",
          "file": "George_r 4PH.CEL",
          "id": "4",
          "treatment": "HU",
          "cohort": "Greek"
        },
        {
          "label": "George_r 6PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M006",
          "classification": "R?",
          "group": null,
          "file": "George_r 6PC.CEL",
          "id": "6",
          "treatment": "Untreated",
          "cohort": "Greek"
        },
        {
          "label": "George_r 6PH",
          "phenotype": "Sickle Cell Anemia, HU+",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_U_M006",
          "classification": "R?",
          "group": null,
          "file": "George_r 6PH.CEL",
          "id": "6",
          "treatment": "HU",
          "cohort": "Greek"
        },
        {
          "label": "George_r 8PC",
          "phenotype": "Sickle Cell Anemia, HU-",
          "material": "Peripheral Blood",
          "date": "Mar. 2009",
          "array_id": "P_S_M_M008",
          "classification": "R",
          "group": "C",
          "file": "George_r 8PC.CEL",
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      "symbol": "CRYZL1",
      "hu_minus_control": 1.2687589,
      "legacy_logfc": -1.2687589
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1552621_at",
      "symbol": "POLR2J2",
      "hu_minus_control": 1.25611473,
      "legacy_logfc": -1.2561147
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1552622_s_at",
      "symbol": "LOC441259 /// POLR2J2",
      "hu_minus_control": 1.41715563,
      "legacy_logfc": -1.4171556
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1552648_a_at",
      "symbol": "TNFRSF10A",
      "hu_minus_control": 0.85336555,
      "legacy_logfc": -0.85336554
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1552770_s_at",
      "symbol": "ZNF563",
      "hu_minus_control": 0.83746326,
      "legacy_logfc": -0.83746326
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1553954_at",
      "symbol": "ALG14",
      "hu_minus_control": -1.1733179,
      "legacy_logfc": 1.1733179
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1554543_at",
      "symbol": "SPAG9",
      "hu_minus_control": 1.01834534,
      "legacy_logfc": -1.0183454
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1554883_a_at",
      "symbol": "ERCC8",
      "hu_minus_control": -0.80996442,
      "legacy_logfc": 0.8099644
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1555199_at",
      "symbol": "GOSR1",
      "hu_minus_control": 0.7835681999999999,
      "legacy_logfc": -0.7835682
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1555679_a_at",
      "symbol": "RTN4IP1",
      "hu_minus_control": -1.08436786,
      "legacy_logfc": 1.0843679
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1557174_a_at",
      "symbol": null,
      "hu_minus_control": -0.7979546799999999,
      "legacy_logfc": 0.7979547
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1557384_at",
      "symbol": "ZNF131",
      "hu_minus_control": 1.3177549800000001,
      "legacy_logfc": -1.317755
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1557505_a_at",
      "symbol": null,
      "hu_minus_control": 1.0605296000000002,
      "legacy_logfc": -1.0605296
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1557701_s_at",
      "symbol": "POLH",
      "hu_minus_control": 1.21225154,
      "legacy_logfc": -1.2122515
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1558135_at",
      "symbol": "TAF11",
      "hu_minus_control": 0.87599551,
      "legacy_logfc": -0.8759955
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1559232_a_at",
      "symbol": null,
      "hu_minus_control": 1.5664117,
      "legacy_logfc": -1.5664117
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1559259_at",
      "symbol": null,
      "hu_minus_control": 1.19165804,
      "legacy_logfc": -1.191658
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1560659_at",
      "symbol": null,
      "hu_minus_control": 0.88586532,
      "legacy_logfc": -0.88586533
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1560661_x_at",
      "symbol": null,
      "hu_minus_control": 1.02788676,
      "legacy_logfc": -1.0278867
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1562412_at",
      "symbol": null,
      "hu_minus_control": 0.8448560199999999,
      "legacy_logfc": -0.844856
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1565358_at",
      "symbol": "RARA",
      "hu_minus_control": 1.9856269000000002,
      "legacy_logfc": -1.9856269
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1565913_at",
      "symbol": null,
      "hu_minus_control": 1.4992033500000002,
      "legacy_logfc": -1.4992033
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1566191_at",
      "symbol": "SUZ12",
      "hu_minus_control": 1.19089672,
      "legacy_logfc": -1.1908967
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1568943_at",
      "symbol": "INPP5D",
      "hu_minus_control": 1.08591103,
      "legacy_logfc": -1.085911
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1568983_a_at",
      "symbol": null,
      "hu_minus_control": 1.4957430600000001,
      "legacy_logfc": -1.495743
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1569527_at",
      "symbol": null,
      "hu_minus_control": 1.1739396,
      "legacy_logfc": -1.1739396
    },
    {
      "file": "HU KLF1 adults.xlsx",
      "probe": "1569607_s_at",
      "symbol": "ANKRD20A1 /// ANKRD20A2 /// ANKRD20A3 /// ANKRD20A4 /// C21orf81 /// LOC100132733 /// LOC284232",
      "hu_minus_control": 1.33880844,
      "legacy_logfc": -1.3388084
    }
  ],
  "clinical": [
    {
      "id": "1",
      "genotype": "IVSI-110/HbS",
      "blood_baseline": 10.0,
      "blood_semester": 22.0,
      "culture_pc": 4.2,
      "culture_hu": 4.7,
      "source_label": ""
    },
    {
      "id": "2",
      "genotype": "IVSI-110/HbS",
      "blood_baseline": 5.5,
      "blood_semester": 14.3,
      "culture_pc": 4.4,
      "culture_hu": 12.9,
      "source_label": ""
    },
    {
      "id": "3",
      "genotype": "HbS/HbS",
      "blood_baseline": 3.5,
      "blood_semester": 13.5,
      "culture_pc": 2.9,
      "culture_hu": 14.9,
      "source_label": ""
    },
    {
      "id": "4",
      "genotype": "IVS2-745/HbS",
      "blood_baseline": 9.4,
      "blood_semester": 17.6,
      "culture_pc": 8.9,
      "culture_hu": 11.2,
      "source_label": "\u2713 NR"
    },
    {
      "id": "6",
      "genotype": "\u03b4\u03b2sic/HbS",
      "blood_baseline": "?",
      "blood_semester": 34.1,
      "culture_pc": 15.0,
      "culture_hu": 31.1,
      "source_label": ""
    },
    {
      "id": "8",
      "genotype": "FSC8/HbS",
      "blood_baseline": 9.5,
      "blood_semester": 34.5,
      "culture_pc": 8.7,
      "culture_hu": 22.4,
      "source_label": "\u2713 R"
    },
    {
      "id": "9",
      "genotype": "FSC8/HbS",
      "blood_baseline": 15.2,
      "blood_semester": 37.3,
      "culture_pc": 8.0,
      "culture_hu": 26.0,
      "source_label": "\u2713 R"
    },
    {
      "id": "18",
      "genotype": "Cd39/HbS",
      "blood_baseline": 7.5,
      "blood_semester": 14.0,
      "culture_pc": 8.0,
      "culture_hu": 15.0,
      "source_label": "\u2713 NR"
    },
    {
      "id": "19",
      "genotype": "Cd39/HbS",
      "blood_baseline": 15.5,
      "blood_semester": 36.5,
      "culture_pc": 18.0,
      "culture_hu": 32.9,
      "source_label": ""
    },
    {
      "id": "20",
      "genotype": "IVSI-110/HbS",
      "blood_baseline": 11.0,
      "blood_semester": 21.0,
      "culture_pc": 11.0,
      "culture_hu": 17.3,
      "source_label": ""
    },
    {
      "id": "21",
      "genotype": "IVSI-6/HbS",
      "blood_baseline": 4.1,
      "blood_semester": 2.6,
      "culture_pc": 1.8,
      "culture_hu": 2.4,
      "source_label": "\u2713 NR"
    },
    {
      "id": "22",
      "genotype": "IVSI-110/HbS",
      "blood_baseline": 8.2,
      "blood_semester": 19.0,
      "culture_pc": 8.0,
      "culture_hu": 14.0,
      "source_label": ""
    },
    {
      "id": "23",
      "genotype": "IVSI-1/HbS",
      "blood_baseline": 10.8,
      "blood_semester": 24.6,
      "culture_pc": 10.0,
      "culture_hu": 25.0,
      "source_label": "\u2713 R"
    },
    {
      "id": "24",
      "genotype": "IVS2-1/HbS",
      "blood_baseline": 1.9,
      "blood_semester": 21.5,
      "culture_pc": 3.0,
      "culture_hu": 16.7,
      "source_label": "\u2713 R"
    },
    {
      "id": "25",
      "genotype": "IVSI-110/HbS",
      "blood_baseline": 6.6,
      "blood_semester": 10.7,
      "culture_pc": 6.0,
      "culture_hu": 11.2,
      "source_label": "\u2713 NR"
    }
  ],
  "hashes": {
    "exp.Analysis FamF(1).txt": "001608d3ca340c6553a063856076fdebeb29df117f201d4f807c9388410eb792",
    "HU non responders Greek.xlsx": "f2e3b136566ae4d282aeabfe86d1f69bd4155321d27e23324335a5f3c5763e72",
    "HU normal adults.xlsx": "4b6c43310cfd41cc5a3e331c53d9b62a79031e24238d9764d7c7ad5906a166f0",
    "RNA Expression Profiler Results - ALL.xlsx": "a4052a5939bae8b11825790094e099961aebd8b52364517e2aa3d138dbfa807a",
    "Cyprus - HU samples Final.xls": "2c592e95cfe6e0df190cf364a90e9568acd7eddf431a8ce0b2255a4622147614",
    "Comparison scheme.pdf": "9b4db7196a2c8d3382e7535972f2bd6135042cc3cd28dc3b412e98742a1bfb34",
    "Human CEL files_Cyprus and Malta.xlsx": "faa44dc2ba275a825fdd8cdff3862a671384b850bdcaaf0e5e90d3296f224823",
    "GREEK_exp.Analysis 1.txt": "59032cc4bc2cf03017ba00093d1f7bb4708ef1b429eb0bfe91a35ab01ac08738",
    "HU responders Greek.xlsx": "322cb8ef634dc43a5246635c6d4f0ce77b98758fc14a0ac948fb579e7155be25",
    "HU KLF1 adults.xlsx": "40176c7e00b6126fe938951f1ed5acc74c5504be6432cee0140da6cd04592400"
  },
  "chunk_size": 500,
  "method": "RMA log2; paired HU minus untreated within original processing batch. Paired t test per group; Welch test on paired changes for interaction. BH across all finite tests among 54,675 probes separately for each contrast. Descriptive/exploratory, n=4 per primary group; family relatedness is not modelled. No re-normalization from CEL files.",
  "limitations": [
    "CEL filenames and processed matrices recovered; raw CEL intensity files are not attached.",
    "PC/PH treatment confirmed by Joseph Borg and metadata workbook; dose and exposure duration absent.",
    "Greek folder name says Greek Thal; metadata says sickle cell anaemia; clinical table contains HbS/HbS and beta-thalassaemia/HbS genotypes.",
    "Original FamF George numbers are not assumed to equal modern M donor labels or pedigree IDs.",
    "Historical probe annotations have not been remapped to current sequence specificity.",
    "HBG/HBB array signals can saturate and cross-hybridize; not quantitative HbF or gamma/beta fractions.",
    "No new ATAC, occupancy, contact, DNA-site or protein-activity measurements are supplied by these expression arrays."
  ]
}